A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance

Chiara Milanese; Pier G Mastroberardino

doi:10.1080/23723556.2020.1733383

A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance

Mol Cell Oncol. 2020 Mar 22;7(3):1733383. doi: 10.1080/23723556.2020.1733383. eCollection 2020.

Authors

Chiara Milanese¹, Pier G Mastroberardino^{1

2}

Affiliations

¹ Department of Molecular Genetics, Erasmus University Medical Center, Rotterdam, Netherlands.
² Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

Abstract

Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of these findings for cancer and chemoresistance development.

Keywords: DNA damage; DNA repair; metabolism; pentose phosphate pathway; redox.