Endoplasmic Reticulum Protein Quality Control in β Cells

Neha Shrestha; Rachel B Reinert; Ling Qi

doi:10.1016/j.semcdb.2020.04.006

Endoplasmic Reticulum Protein Quality Control in β Cells

Semin Cell Dev Biol. 2020 Jul:103:59-67. doi: 10.1016/j.semcdb.2020.04.006. Epub 2020 May 8.

Authors

Neha Shrestha¹, Rachel B Reinert², Ling Qi³

Affiliations

¹ Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA.
² Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA.
³ Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA. Electronic address: [email protected].

Abstract

Type 1 and type 2 diabetes are associated with loss of β cell function. Optimal β cell function is linked to protein homeostasis in the endoplasmic reticulum (ER). Here, we review the roles of ER protein quality-control mechanisms, including the unfolded protein response (UPR), autophagy (specifically ER-phagy) and ER-associated degradation (ERAD), in β cells. We propose that different quality control mechanisms may control different aspects of β cell biology (i.e. function, survival, and identity), thereby contributing to disease pathogenesis.

Keywords: ER; ER-phagy; ERAD; UPR; diabetes; β cells.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Diabetes Mellitus / metabolism*
Endoplasmic Reticulum / metabolism*
Humans
Insulin-Secreting Cells / metabolism*
Membrane Proteins / metabolism*

Substances

Membrane Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding