Abstract
Cervical cancer screening was revolutionized in the early 1980s with the discovery of human papillomaviruses (HPVs) as the single causative agent of the disease. Viral infections contribute to ~12% of cancers worldwide, and two DNA viruses, Epstein-Barr virus and HPV, are associated with 38% of all virus-associated cancers. Most viral-associated cancers develop after a long latency period (15-40 yr).
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
B7-H1 Antigen / biosynthesis
-
Early Detection of Cancer / methods
-
Epstein-Barr Virus Infections / diagnosis
-
Epstein-Barr Virus Infections / epidemiology*
-
Epstein-Barr Virus Infections / physiopathology
-
Female
-
Herpesvirus 4, Human / physiology*
-
Humans
-
Papillomaviridae / physiology*
-
Papillomavirus Infections / diagnosis
-
Papillomavirus Infections / epidemiology*
-
Papillomavirus Infections / physiopathology
-
Uterine Cervical Neoplasms / diagnosis
-
Uterine Cervical Neoplasms / epidemiology*
-
Uterine Cervical Neoplasms / physiopathology
Substances
-
B7-H1 Antigen
-
CD274 protein, human