Neutrophils Create an ImpeNETrable Shield between Tumor and Cytotoxic Immune Cells

Abbie S Ireland; Trudy G Oliver

doi:10.1016/j.immuni.2020.04.009

Neutrophils Create an ImpeNETrable Shield between Tumor and Cytotoxic Immune Cells

Immunity. 2020 May 19;52(5):729-731. doi: 10.1016/j.immuni.2020.04.009.

Authors

Abbie S Ireland¹, Trudy G Oliver²

Affiliations

¹ Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
² Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: [email protected].

Abstract

Neutrophil extracellular traps (NETs) can promote tumor growth and metastases, but whether NETs impact the tumor immune microenvironment remains underexplored. In this issue of Immunity, Teijeira et al. discover that NETs shield tumor cells from cytotoxic immune cells, resulting in impaired tumor clearance.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Chemokines
Extracellular Traps*
Humans
Neoplasms*
Neutrophils
Tumor Microenvironment

Substances

Chemokines

Grants and funding

R01 CA244841/CA/NCI NIH HHS/United States