Donor-Derived Transmission of Cryptococcus gattii sensu lato in Kidney Transplant Recipients

Emerg Infect Dis. 2020 Jun;26(6):1329-1331. doi: 10.3201/eid2606.191765.

Abstract

We describe cases of donor-derived transmission of Cryptococcus deuterogattii in 2 kidney transplant recipients in Brazil and published information on other cases. Prompt reduction of immunosuppression and initiation of antifungal therapy was required to successfully control the fungal infections and preserve engraftment.

Keywords: Antifungal therapy; Brazil; Cryptococcus gattii; HIV/AIDS and other retroviruses; donor-transmitted disease; fungal infection; fungi; immunosuppression; kidney transplantation.

MeSH terms

  • Antifungal Agents / therapeutic use
  • Brazil
  • Cryptococcosis* / diagnosis
  • Cryptococcosis* / drug therapy
  • Cryptococcus gattii* / genetics
  • Cryptococcus neoformans*
  • Humans
  • Kidney Transplantation* / adverse effects
  • Transplant Recipients

Substances

  • Antifungal Agents