Genetic characterization of Parkinson's disease patients in Ecuador and Colombia

Parkinsonism Relat Disord. 2020 Jun:75:27-29. doi: 10.1016/j.parkreldis.2020.05.005. Epub 2020 May 15.

Abstract

To help address the scarcity of studies on the genetics of Parkinson's disease (PD) in Latin America, we screened 426 Ecuadorians with PD and 80 Colombians (PD = 55, Control = 26) for mutations within several PD-related genes. Among Colombians, we identified several variants within PARKIN and PINK1 genes.

Keywords: Genetics; Latin America; Parkinson's disease.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Aged, 80 and over
  • Colombia
  • Ecuador
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / genetics*
  • Protein Kinases / genetics
  • Ubiquitin-Protein Ligases / genetics

Substances

  • Ubiquitin-Protein Ligases
  • parkin protein
  • Protein Kinases
  • PTEN-induced putative kinase