Objective: To analyze the heritability of coronary heart disease (CHD) among the Chinese twin adults. Methods: A total of 20 477 same-sex twin pairs aged 25 years and older from the Chinese National Twin Registry were interviewed. Structure equation model was used to estimate the heritability of CHD. Results: After adjusting for age and gender, the overall heritability of CHD was 0.75(0.68-0.81). Stratified analyses showed that genetic factors play a more important role in CHD incidence in ≥40 years or female twins. While the development of CHD was mainly influenced by environmental factors in 25-39 years or male twins. Conclusion: CHD is influenced by both genetic and environmental factors and the heritability is high.
目的： 分析中国成年双生子人群的冠心病遗传度。 方法： 利用中国双生子登记系统在11省、市募集的20 477对≥25岁同性别双生子，构建结构方程模型计算遗传度。 结果： 调整年龄、性别后，冠心病的遗传度为0.75（0.68~0.81）。亚组分析显示≥40岁组和女性人群中，冠心病患病主要受遗传因素的影响；而25~39岁组和男性的患病主要受环境因素的影响。 结论： 冠心病患病受遗传和环境因素的影响，且遗传度较高。.
Keywords: Coronary heart disease; Heritability; Twin study.