Large vessel vasculitis secondary to granulocyte-colony stimulating factor

Vasa. 2020 Oct;49(6):509-513. doi: 10.1024/0301-1526/a000872. Epub 2020 May 26.

Abstract

Aortitis is a rare entity that may cause fever of unknown origin. This entity has a wide various etiologies, which main cause is rheumatologic, but not only. Iatrogenia has also been described, including chemotherapy and supporting treatment (like granulocyte-colony stimulating factor in oncological patients. The evidence in favour of this pharmacological link is growing. The differential diagnosis of fever, in febrile neutropenia setting, can be difficult to itemize.

Keywords: Aortitis; computed tomography (CT); granulocyte-colony stimulating factor (G-CSF); positron emission tomography (PET); vasculitis.

MeSH terms

  • Aortitis / diagnosis
  • Aortitis / diagnostic imaging
  • Fever
  • Granulocyte Colony-Stimulating Factor / adverse effects
  • Granulocytes*
  • Humans
  • Neutropenia*

Substances

  • Granulocyte Colony-Stimulating Factor