Complete remission of refractory juvenile acute myeloid leukaemia with RUNX1-PRDM16 in Bloom syndrome after haematopoietic stem cell transplantation

Br J Haematol. 2020 Aug;190(3):e166-e169. doi: 10.1111/bjh.16789. Epub 2020 May 26.
No abstract available

Keywords: RUNX1-PRDM16 fusion; acute myeloid leukaemia; allogeneic haematopoietic stem cell transplantation; bloom syndrome.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abnormal Karyotype
  • Allografts
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Base Sequence
  • Bloom Syndrome / complications*
  • Bloom Syndrome / genetics
  • Child
  • Core Binding Factor Alpha 2 Subunit / genetics*
  • DNA-Binding Proteins / genetics*
  • Drug Resistance, Neoplasm
  • Exome Sequencing
  • Exons / genetics
  • Hematopoietic Stem Cell Transplantation*
  • Heterozygote
  • Humans
  • Leukemia, Monocytic, Acute / drug therapy
  • Leukemia, Monocytic, Acute / etiology
  • Leukemia, Monocytic, Acute / genetics
  • Leukemia, Monocytic, Acute / therapy*
  • Male
  • Oncogene Proteins, Fusion / genetics*
  • Protein Domains
  • Remission Induction
  • Salvage Therapy*
  • Transcription Factors / genetics*

Substances

  • Core Binding Factor Alpha 2 Subunit
  • DNA-Binding Proteins
  • Oncogene Proteins, Fusion
  • PRDM16 protein, human
  • RUNX1 protein, human
  • Transcription Factors