Abstract
A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.
MeSH terms
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Apoptosis / drug effects
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Cell Line, Tumor
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Female
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Gene Transfer Techniques*
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Genetic Therapy
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Humans
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Nanoparticles / chemistry*
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Ovarian Neoplasms / drug therapy*
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Ovarian Neoplasms / metabolism
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Ovarian Neoplasms / pathology
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Polymers / chemistry*
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RNA, Small Interfering / chemistry
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RNA, Small Interfering / genetics
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RNA, Small Interfering / pharmacology*
Substances
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Polymers
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RNA, Small Interfering