Improvement of Impaired Motor Functions by Human Dental Exfoliated Deciduous Teeth Stem Cell-Derived Factors in a Rat Model of Parkinson's Disease

Int J Mol Sci. 2020 May 27;21(11):3807. doi: 10.3390/ijms21113807.

Abstract

Parkinson's disease (PD) is a long-term degenerative disease of the central nervous system (CNS) that primarily affects the motor system. So far there is no effective treatment for PD, only some drugs, surgery, and comprehensive treatment can alleviate the symptoms of PD. Stem cells derived from human exfoliated deciduous teeth (SHED), mesenchymal stem cells derived from dental pulp, may have promising potential in regenerative medicine. In this study, we examine the therapeutic effect of SHED-derived conditioned medium (SHED-CM) in a rotenone-induced PD rat model. Intravenous administration of SHED-CM generated by standardized procedures significantly improved the PD symptoms accompanied with increased tyrosine hydroxylase amounts in the striatum, and decreased α-synuclein levels in both the nigra and striatum, from rotenone-treated rats. In addition, this SHED-CM treatment decreased both Iba-1 and CD4 levels in these brain areas. Gene ontology analysis indicated that the biological process of genes affected by SHED-CM was primarily implicated in neurodevelopment and nerve regeneration. The major constituents of SHED-CM included insulin-like growth factor binding protein-6 (IGFBP-6), tissue inhibitor of metalloproteinase (TIMP)-2, TIMP-1, and transforming growth factor 1 (TGF-1). RNA-sequencing (RNA-seq) and Ingenuity Pathway Analysis (IPA) revealed that these factors may ameliorate PD symptoms through modulating the cholinergic synapses, calcium signaling pathways, serotoninergic synapses, and axon guidance. In conclusion, our data indicate that SHED-CM contains active constituents that may have promising efficacy to alleviate PD.

Keywords: human exfoliated deciduous teeth, stem cell, Parkinson's disease (PD), rotenone.

MeSH terms

  • Animals
  • Cells, Cultured
  • Corpus Striatum / drug effects
  • Corpus Striatum / metabolism
  • Culture Media, Conditioned / chemistry
  • Culture Media, Conditioned / pharmacology*
  • Female
  • Humans
  • Injections, Intravenous
  • Insulin-Like Growth Factor Binding Protein 6 / analysis
  • Mesenchymal Stem Cells / metabolism*
  • Neuroprotective Agents / administration & dosage
  • Neuroprotective Agents / pharmacology
  • Neuroprotective Agents / therapeutic use*
  • Parkinson Disease / drug therapy*
  • Rats
  • Rats, Inbred Lew
  • Tissue Inhibitor of Metalloproteinases / analysis
  • Tooth, Deciduous / cytology*
  • Transforming Growth Factor beta / analysis
  • Tyrosine 3-Monooxygenase / metabolism
  • alpha-Synuclein / metabolism

Substances

  • Culture Media, Conditioned
  • Insulin-Like Growth Factor Binding Protein 6
  • Neuroprotective Agents
  • Tissue Inhibitor of Metalloproteinases
  • Transforming Growth Factor beta
  • alpha-Synuclein
  • Tyrosine 3-Monooxygenase