Molar and nonmolar triploidy: Recurrence or bad luck

Brianne Robinson; Jo-Ann Brock; Craig Midgen; Jillian Coolen

doi:10.1002/ccr3.2703

Molar and nonmolar triploidy: Recurrence or bad luck

Clin Case Rep. 2020 Feb 11;8(5):785-789. doi: 10.1002/ccr3.2703. eCollection 2020 May.

Authors

Brianne Robinson¹, Jo-Ann Brock², Craig Midgen³, Jillian Coolen⁴

Affiliations

¹ Dalhousie Medical School Halifax NS Canada.
² Departments of Anatomic Pathology and Obstetrics and Gynaecology Dalhousie University Halifax NS Canada.
³ Department of Anatomic Pathology Dalhousie University Halifax NS Canada.
⁴ Department of Obstetrics and Gynaecology Dalhousie University Halifax NS Canada.

Abstract

In triploid pregnancies, the parental origin of the extra genome determines the phenotype and placental and fetal outcomes. Molecular genetics and placental pathology enable differentiation of molar vs nonmolar pregnancy to guide future planning.

Keywords: genomic imprinting; hydatidiform mole; triploidy.

Publication types

Case Reports