Plasma Proteomic Analysis Reveals Age-Specific Changes in Platelet- and Endothelial Cell-Derived Proteins and Regulators of Plasma Coagulation and Fibrinolysis

Conor McCafferty; Xavier Busuttil-Crellin; Tengyi Cai; Paul Monagle; Neil A Goldenberg; Vera Ignjatovic

doi:10.1016/j.jpeds.2020.01.051

Plasma Proteomic Analysis Reveals Age-Specific Changes in Platelet- and Endothelial Cell-Derived Proteins and Regulators of Plasma Coagulation and Fibrinolysis

J Pediatr. 2020 Jun:221S:S29-S36. doi: 10.1016/j.jpeds.2020.01.051.

Authors

Conor McCafferty¹, Xavier Busuttil-Crellin¹, Tengyi Cai¹, Paul Monagle², Neil A Goldenberg³, Vera Ignjatovic⁴

Affiliations

¹ Haematology Research Laboratory, Murdoch Children's Research Institute, Melbourne, Australia.
² Haematology Research Laboratory, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia; Department of Clinical Haematology, Royal Children's Hospital, Melbourne, Australia.
³ Divisions of Hematology, Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, St. Petersburg, FL; Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL.
⁴ Haematology Research Laboratory, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia. Electronic address: [email protected].

PMID: 32482231
DOI: 10.1016/j.jpeds.2020.01.051

Abstract

This post hoc study of a plasma proteomic database investigated hemostatic proteins in the context of developmental hemostasis. Twenty-seven hemostatic proteins changed expression with age, and the hemostatic profile of neonates was unique. Appreciating developmental hemostasis through proteomics may lead to more personalized medicine for hospitalized children.

Keywords: hemostasis; pediatrics; plasma; platelet; proteomics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aging / blood*
Blood Coagulation / physiology
Blood Platelets / physiology
Blood Proteins / physiology*
Child
Child, Preschool
Endothelial Cells / physiology
Female
Fibrinolysis / physiology
Hemostasis / physiology*
Humans
Infant
Infant, Newborn
Male
Middle Aged
Principal Component Analysis
Proteomics*
Young Adult

Substances

Blood Proteins