Medicinal chemistry strategies of targeting HIV-1 capsid protein for antiviral treatment

Future Med Chem. 2020 Jul;12(14):1281-1284. doi: 10.4155/fmc-2020-0084. Epub 2020 Jun 2.

Authors

Shujing Xu¹, Lin Sun¹, Boshi Huang², Xinyong Liu¹, Peng Zhan¹

Affiliations

¹ Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, PR China.
² Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, USA.

PMID: 32483985
DOI: 10.4155/fmc-2020-0084

No abstract available

Keywords: CA inhibitor; drug design; medicinal chemistry strategy.

Publication types

Editorial
Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-HIV Agents / chemistry
Anti-HIV Agents / pharmacology*
Biological Products / chemistry
Biological Products / pharmacology*
Capsid Proteins / antagonists & inhibitors*
Capsid Proteins / metabolism
Chemistry, Pharmaceutical*
Drug Evaluation, Preclinical
HIV-1 / drug effects*
High-Throughput Screening Assays
Humans
Microbial Sensitivity Tests

Substances

Anti-HIV Agents
Biological Products
Capsid Proteins