Diabetes and severity of COVID-19: What is the link?

D Pitocco; L Viti; L Tartaglione; M Di Leo; G E Rizzo; A Manto; A Rizzi; S Caputo; A Pontecorvi

doi:10.1016/j.mehy.2020.109923

Diabetes and severity of COVID-19: What is the link?

Med Hypotheses. 2020 Oct:143:109923. doi: 10.1016/j.mehy.2020.109923. Epub 2020 May 30.

Authors

D Pitocco¹, L Viti², L Tartaglione², M Di Leo², G E Rizzo², A Manto², A Rizzi², S Caputo², A Pontecorvi³

Affiliations

¹ Diabetes Care Unit, Fondazione Policlinico A.Gemelli IRCCS, Rome, Italy. Electronic address: [email protected].
² Diabetes Care Unit, Fondazione Policlinico A.Gemelli IRCCS, Rome, Italy.
³ Department of Endocrinology, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.

Abstract

In Diabetes Mellitus the loss of capacity to regulate immunity, the reduction of pulmonary functions and the pro-thrombotic state determine the severity of COVID-19.

Publication types

Letter

MeSH terms

Betacoronavirus*
COVID-19
Coronavirus Infections / complications*
Coronavirus Infections / immunology
Coronavirus Infections / physiopathology*
Diabetes Complications / immunology
Diabetes Complications / physiopathology*
Diabetes Mellitus / immunology
Diabetes Mellitus / physiopathology
Disseminated Intravascular Coagulation / etiology
Disseminated Intravascular Coagulation / immunology
Disseminated Intravascular Coagulation / physiopathology
Humans
Models, Biological
Neuroimmunomodulation
Pandemics
Pneumonia, Viral / complications*
Pneumonia, Viral / immunology
Pneumonia, Viral / physiopathology*
Respiratory Distress Syndrome / etiology
Respiratory Distress Syndrome / immunology
Respiratory Distress Syndrome / physiopathology
Risk Factors
SARS-CoV-2
Thrombosis / etiology
Thrombosis / immunology
Thrombosis / physiopathology