Abstract
By addition of methylisocyanate to 5-arylidene 2-aminoalkyl 3-pyridazinones a series of derivatives substituted in the 2-position by an ureidoalkyl moiety was obtained in good yields. Gastric antisecretory and anti-ulcer activities of these new compounds were evaluated. The influence of the substituents attached to the pyridazine ring was discussed.
MeSH terms
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Animals
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Anti-Ulcer Agents / chemical synthesis*
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Chemical Phenomena
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Chemistry
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Female
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Gastric Mucosa / drug effects
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Gastric Mucosa / metabolism
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Male
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Pyridazines / chemical synthesis*
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Pyridazines / pharmacology
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Rats
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Rats, Inbred Strains
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Urea / analogs & derivatives*
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Urea / chemical synthesis
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Urea / pharmacology
Substances
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Anti-Ulcer Agents
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Pyridazines
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Urea