Interferon-γ and voriconazole combined therapy for refractory meningeal coccidioidomycosis in a patient with interferon-γ deficiency

Alejandro De la Hoz; Alexandre Malek; Rodrigo Hasbun

doi:10.1016/j.idcr.2020.e00835

Interferon-γ and voriconazole combined therapy for refractory meningeal coccidioidomycosis in a patient with interferon-γ deficiency

IDCases. 2020 May 21:21:e00835. doi: 10.1016/j.idcr.2020.e00835. eCollection 2020.

Authors

Alejandro De la Hoz¹, Alexandre Malek², Rodrigo Hasbun²

Affiliations

¹ Grupo de Investigación en Enfermedades Infecciosas, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá, Colombia.
² Division of Infectious Diseases, Department of Internal Medicine, McGovern Medical School at UT Health, Houston TX, USA.

Abstract

Coccidioides meningitis (CM) is a challenging infection, given the limited penetration to the cerebrospinal fluid of conventional antifungals, resulting in a high risk of recurrence. We present the first case of a successfully treated persistent CM with voriconazole and adjuvant INF-γ 1b.

Keywords: Coccidioidomycosis; Gamma-interferon; Meningitis.

Publication types

Case Reports