Sustainability of a Clinical Examination-Based Approach for Ascertainment of Early-Onset Sepsis in Late Preterm and Term Neonates

Adam Frymoyer; Neha S Joshi; Jessica M Allan; Ronald S Cohen; Janelle L Aby; Juliann L Kim; William E Benitz; Arun Gupta

doi:10.1016/j.jpeds.2020.05.055

Sustainability of a Clinical Examination-Based Approach for Ascertainment of Early-Onset Sepsis in Late Preterm and Term Neonates

J Pediatr. 2020 Oct:225:263-268. doi: 10.1016/j.jpeds.2020.05.055. Epub 2020 Jun 5.

Authors

Adam Frymoyer¹, Neha S Joshi², Jessica M Allan³, Ronald S Cohen², Janelle L Aby², Juliann L Kim³, William E Benitz², Arun Gupta²

Affiliations

¹ Department of Pediatrics, Stanford University, Stanford, CA. Electronic address: [email protected].
² Department of Pediatrics, Stanford University, Stanford, CA.
³ Palo Alto Medical Foundation, Palo Alto, CA.

PMID: 32511960
DOI: 10.1016/j.jpeds.2020.05.055

Abstract

We demonstrated the sustained impact over a 5-year period of a clinical examination-based approach to identification of early-onset sepsis in late preterm and term neonates at our hospital. To date, more than 20 000 neonates have been safely managed using this approach, resulting in a 63% reduction in antibiotic use.

Keywords: antibiotics; antimicrobial stewardship.

MeSH terms

Anti-Bacterial Agents / therapeutic use
Cohort Studies
Female
Humans
Infant, Newborn
Infant, Premature
Interrupted Time Series Analysis
Neonatal Screening / methods*
Neonatal Sepsis / diagnosis*
Neonatal Sepsis / drug therapy
Pregnancy
Quality Improvement

Substances

Anti-Bacterial Agents