HRI stress signaling and HbF production

Blood. 2020 Jun 11;135(24):2113-2114. doi: 10.1182/blood.2020006300.

Abstract

In this issue of Blood, Huang et al have identified activating transcription factor 4 (ATF4) as a novel regulator of fetal γ-globin gene expression in human cells by repressing BCL11A transcription.

Publication types

  • Comment

MeSH terms

  • Fetal Hemoglobin*
  • Gene Expression Regulation
  • Signal Transduction
  • Transcription Factors*
  • eIF-2 Kinase / genetics

Substances

  • Transcription Factors
  • Fetal Hemoglobin
  • eIF-2 Kinase