Elevated nucleoprotein-induced interferon-γ release in COVID-19 patients detected in a SARS-CoV-2 enzyme-linked immunosorbent spot assay

J Infect. 2020 Sep;81(3):452-482. doi: 10.1016/j.jinf.2020.06.015. Epub 2020 Jun 12.

Authors

Steven Thijsen¹, Michiel Heron¹, Hendrik Gremmels¹, Robert van der Kieft¹, Chantal Reusken², Kristin Kremer², Gijs Limonard³, Ailko Bossink³

Affiliations

¹ Department of Medical Microbiology & Immunology, Diakonessenhuis Utrecht, Netherlands.
² Centre for Infectious Disease Control, WHO reference laboratory for COVID-19, National Institute for Public Health and the Environment (RIVM), Antonie v. Leeuwenhoeklaan 9, 3721 MA, Bilthoven, Netherlands.
³ Department of Pulmonary Diseases, Diakonessenhuis Utrecht, Netherlands.

No abstract available

Keywords: Covid-19; ELISpot; Interferon-gamma release assay; Sars-cov-2; T-cell response.

Publication types

Letter
Comment

MeSH terms

Betacoronavirus
COVID-19
Coronavirus Infections / epidemiology*
Humans
Immunosorbents
Interferon-gamma
Nucleoproteins
Pandemics*
Pneumonia, Viral / epidemiology*
SARS-CoV-2

Substances

Immunosorbents
Nucleoproteins
Interferon-gamma