Application of mesoporous silica nanoparticles as drug delivery carriers for chemotherapeutic agents

Yasmine Alyassin; Elshaimaa G Sayed; Prina Mehta; Ketan Ruparelia; Muhammad S Arshad; Manoochehr Rasekh; Jennifer Shepherd; Israfil Kucuk; Philippe B Wilson; Neenu Singh; Ming-Wei Chang; Dimitrios G Fatouros; Zeeshan Ahmad

doi:10.1016/j.drudis.2020.06.006

Application of mesoporous silica nanoparticles as drug delivery carriers for chemotherapeutic agents

Drug Discov Today. 2020 Aug;25(8):1513-1520. doi: 10.1016/j.drudis.2020.06.006. Epub 2020 Jun 16.

Affiliations

¹ Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK.
² Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK; Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt.
³ Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK; College of Engineering, Design and Physical Sciences, Brunel University London, Middlesex UB8 3PH, UK.
⁴ Department of Engineering, University of Leicester, Leicester, LE1 7RH, UK.
⁵ Institute of Nanotechnology, Gebze Technical University, 41400 Gebze, Turkey.
⁶ School of Animal, Rural and Environmental Sciences, Nottingham Trent University, Brackenhurst Campus, Southwell, NG25 0QF, UK.
⁷ Nanotechnology and Integrated Bioengineering Centre, University of Ulster, Jordanstown Campus, Newtownabbey, BT37 0QB, UK.
⁸ Department of Pharmaceutical Technology, Aristotle University of Thessaloniki, School of Pharmacy, 54124, Thessaloniki, Greece.
⁹ Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK. Electronic address: [email protected].

PMID: 32561300
DOI: 10.1016/j.drudis.2020.06.006

Abstract

Recently, remarkable efforts have focused on research towards enhancing and delivering efficacious and advanced therapeutic agents. Even though this involves significant challenges, innovative techniques and materials have been explored to overcome these. The advantageous properties of mesoporous silica nanoparticles (MSNs), such as unique morphologies and geometries, makes then favorable for use for various drug delivery targeting purposes, particularly in cancer therapy. As we discuss here, MSNs have been utilized over the past few decades to improve the efficiency of anticancer drugs by enhancing their solubility to render them suitable for application, reducing adverse effects, and improving their anticancer cytotoxic efficiency.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antineoplastic Agents / administration & dosage*
Drug Carriers / administration & dosage*
Humans
Porosity
Silicon Dioxide / administration & dosage*

Substances

Antineoplastic Agents
Drug Carriers
Silicon Dioxide