COVID-19 - Does This Disease Kill Due to Imbalance of the Renin Angiotensin System (RAS) Caused by Genetic and Gender Differences in the Response to Viral ACE 2 Attack?

Ruth H Arnold

doi:10.1016/j.hlc.2020.05.004

COVID-19 - Does This Disease Kill Due to Imbalance of the Renin Angiotensin System (RAS) Caused by Genetic and Gender Differences in the Response to Viral ACE 2 Attack?

Heart Lung Circ. 2020 Jul;29(7):964-972. doi: 10.1016/j.hlc.2020.05.004. Epub 2020 May 25.

Author

Ruth H Arnold¹

Affiliation

¹ Orange Health Service, Orange, NSW, Australia. Electronic address: [email protected].

Abstract

Debate continues in the medical literature on the role of the renin angiotensin system (RAS) in Coronavirus disease 2019 (COVID-19) pathophysiology and the implications for the use of cardiovascular drugs acting on the RAS. Could these drugs - which include angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptors blockers (ARBs) - be harmful or potential key therapeutic agents in COVID-19? And, could potentially helpful measures be available and in plain view on the pharmacy shelf?

Keywords: Angiotensin converting enzyme inhibitors; Angiotensin receptor blockers; COVID 19; Neprilysin; Renin angiotensin system; Vitamin D.

Copyright © 2020 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.

MeSH terms

Angiotensin-Converting Enzyme 2
Betacoronavirus / physiology*
COVID-19
Coronavirus Infections* / metabolism
Coronavirus Infections* / mortality
Coronavirus Infections* / virology
Humans
Mortality
Pandemics*
Peptidyl-Dipeptidase A* / genetics
Peptidyl-Dipeptidase A* / metabolism
Pneumonia, Viral* / metabolism
Pneumonia, Viral* / mortality
Pneumonia, Viral* / virology
Renin-Angiotensin System / physiology*
Risk Factors*
SARS-CoV-2
Virus Internalization

Substances

Peptidyl-Dipeptidase A
ACE2 protein, human
Angiotensin-Converting Enzyme 2