We describe 2 cases of healthcare-associated Legionnaires' disease in patients in France hospitalized 5 months apart in the same room. Whole-genome sequencing analyses showed that clinical isolates from the patients and isolates from the room's toilet clustered together. Toilet contamination by Legionella pneumophila could lead to a risk for exposure through flushing.
Keywords: Bacteria; Legionella pneumophila; Legionnaires’ disease; healthcare-associated infections; nosocomial infections; phylogeny; pneumophilia; respiratory infections; toilet; transmission.