Induced pluripotent stem cells provide mega insights into kidney disease

Alessandro Luciani; Benjamin S Freedman

doi:10.1016/j.kint.2020.04.033

Induced pluripotent stem cells provide mega insights into kidney disease

Kidney Int. 2020 Jul;98(1):54-57. doi: 10.1016/j.kint.2020.04.033.

Authors

Alessandro Luciani¹, Benjamin S Freedman²

Affiliations

¹ Institute of Physiology, Mechanisms of Inherited Kidney Disorders Group, University of Zurich, Zurich, Switzerland. Electronic address: [email protected].
² Division of Nephrology, University of Washington School of Medicine, Seattle, Washington, USA; Kidney Research Institute, University of Washington School of Medicine, Seattle, Washington, USA; Institute of Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington, USA; Department of Pathology (Adjunct), University of Washington School of Medicine, Seattle, Washington, USA; Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.

Abstract

Rare mutations in the LRP2 gene encoding for the endocytic receptor megalin cause developmental abnormalities and kidney disease. However, the mechanisms governing the dysfunction of mutant megalin remain unclear. A new study utilizing patient-derived induced pluripotent stem cells is now putting the endolysosomal system into the spotlight, as it is proposed to play a central role in the regulation of megalin in health and disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Induced Pluripotent Stem Cells*
Kidney Diseases* / genetics
Kidney Diseases* / therapy
Low Density Lipoprotein Receptor-Related Protein-2 / genetics
Mutation

Substances

Low Density Lipoprotein Receptor-Related Protein-2

Abstract

Publication types

MeSH terms

Substances

Grants and funding