Heterophile Hanganutziu-Deicher antigen in ganglioside fractions of human melanoma tissues

S Kawachi; T Saida; H Uhara; K Uemura; T Taketomi; K Kano

doi:10.1159/000234536

Heterophile Hanganutziu-Deicher antigen in ganglioside fractions of human melanoma tissues

Int Arch Allergy Appl Immunol. 1988;85(3):381-3. doi: 10.1159/000234536.

Authors

S Kawachi¹, T Saida, H Uhara, K Uemura, T Taketomi, K Kano

Affiliation

¹ Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.

PMID: 3258290
DOI: 10.1159/000234536

Abstract

Gangliosides were purified from melanoma tissue extracts obtained from 5 patients. GM3 and GD3 were identified as the major components in ganglioside fractions of the melanoma tissues. Following thin-layer chromatography, enzyme immunostaining with Hanganutziu-Deicher (H-D) antigen-specific chicken antisera demonstrated the presence of NeuGc-neolactotetraosylceramide (H-D5) and NeuGc-lacto-N-norhexa-osylceramide (H-D7) in all 5 melanoma extracts.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Heterophile / immunology*
Antigens, Heterophile / analysis*
Antigens, Neoplasm / analysis*
Gangliosides / analysis*
Humans
Melanoma / analysis
Melanoma / immunology*

Substances

Antibodies, Heterophile
Antigens, Heterophile
Antigens, Neoplasm
Gangliosides