Acute d-fenfluramine, but not fluoxetine decreases sweet intake in BALB/c, C57BL/6 and SWR inbred mouse strains

Physiol Behav. 2020 Oct 1:224:113029. doi: 10.1016/j.physbeh.2020.113029. Epub 2020 Jun 24.

Abstract

Dopamine, opioid and muscarinic receptor antagonists differentially reduce sucrose and saccharin intakes across inbred mouse strains. Whereas these systems stimulate sweet intake, serotonin signaling inhibits food intake. The present study examined whether fluoxetine (0.1-10 mg/kg) or d-fenfluramine (0.1-6 mg/kg) differentially inhibited sucrose or saccharin intake in BALB/c, C57BL/6 and SWR mice. Fluoxetine marginally altered sucrose intake in all strains. d-fenfluramine significantly, but quite similarly reduced (ID40) sucrose and saccharin intake in BALB/c (5.7 vs. 5.8 mg/kg), C57BL/6 (4.4 vs. 4.3 mg/kg) and SWR (4.6 vs. 5.6 mg/kg) mice, suggesting serotonin-induced inhibition of orosensory mechanisms in all three inbred mouse strains.

Keywords: Murine genetic variance; Saccharin intake; Serotonin; Sucrose intake.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Fenfluramine
  • Fluoxetine* / pharmacology
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Narcotic Antagonists*
  • Sucrose

Substances

  • Narcotic Antagonists
  • Fluoxetine
  • Fenfluramine
  • Sucrose