Examination of preliminary behavioral and effective connectivity findings from treatment response to citalopram in cocaine use disorder: A dynamic causal modeling study

A D Snyder; E Zuniga; L Ma; J L Steinberg; K Woisard; P A Narayana; S Lane; J Schmitz; F G Moeller

doi:10.1016/j.pscychresns.2020.111127

Examination of preliminary behavioral and effective connectivity findings from treatment response to citalopram in cocaine use disorder: A dynamic causal modeling study

Psychiatry Res Neuroimaging. 2020 Sep 30:303:111127. doi: 10.1016/j.pscychresns.2020.111127. Epub 2020 Jun 15.

Authors

A D Snyder¹, E Zuniga², L Ma³, J L Steinberg⁴, K Woisard⁵, P A Narayana⁶, S Lane⁷, J Schmitz⁸, F G Moeller⁹

Affiliations

¹ Institute for Drug and Alcohol Studies; Department of Psychiatry. Electronic address: [email protected].
² Institute for Drug and Alcohol Studies.
³ Institute for Drug and Alcohol Studies; Department of Radiology.
⁴ Institute for Drug and Alcohol Studies; Department of Psychiatry.
⁵ Institute for Drug and Alcohol Studies; Virginia Commonwealth University School of Medicine, Richmond, VA, United States.
⁶ Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX, United States.
⁷ Program in Neuroscience, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States.
⁸ Faillace Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States.
⁹ Institute for Drug and Alcohol Studies; Department of Psychiatry; Department of Pharmacology and Toxicology; Department of Neurology, Virginia Commonwealth University, Richmond, VA, United States. Electronic address: [email protected].

Abstract

We sought effective (directional) connectivity parameters associated with response to citalopram in cocaine use disorder (CUD) by conducting a functional magnetic resonance imaging (fMRI) experiment with participants diagnosed with CUD (n = 13) and matched healthy controls (HC; n = 17). CUD participants showed a positive correlation between bilateral DLPFC-to-putamen effective connectivity and treatment effectiveness score. These preliminary results support further investigation of prefrontal-striatal interactions in response to treatment in CUD.

Keywords: Citalopram; Cocaine use disorder; Effective connectivity; Impulsivity; Selective serotonin reuptake inhibitor; Ssri.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adult
Citalopram / pharmacology
Citalopram / therapeutic use*
Cocaine-Related Disorders / diagnostic imaging
Cocaine-Related Disorders / drug therapy*
Corpus Striatum / diagnostic imaging
Corpus Striatum / drug effects*
Female
Humans
Impulsive Behavior / drug effects
Impulsive Behavior / physiology
Magnetic Resonance Imaging / methods*
Male
Nerve Net / diagnostic imaging
Nerve Net / drug effects
Prefrontal Cortex / diagnostic imaging
Prefrontal Cortex / drug effects*
Selective Serotonin Reuptake Inhibitors / pharmacology
Selective Serotonin Reuptake Inhibitors / therapeutic use*
Treatment Outcome
Young Adult

Substances

Serotonin Uptake Inhibitors
Citalopram

Abstract

Publication types

MeSH terms

Substances

Grants and funding