de novo MAPT mutation G335A causes severe brain atrophy, 3R and 4R PHF-tau pathology and early onset frontotemporal dementia

Affiliations

• ¹ Laboratory of Histology, Neuroanatomy and Neuropathology, Faculty of Medicine, Université Libre de Bruxelles, ULB Neuroscience Institute, 808 route de Lennik, Bldg GE, B-1070, Brussels, Belgium. [email protected].
• ² Department of Neurology, Université Libre de Bruxelles, Hôpital Erasme, 808 route de Lennik, B-1070, Brussels, Belgium.
• ³ Laboratory of Histology, Neuroanatomy and Neuropathology, Faculty of Medicine, Université Libre de Bruxelles, ULB Neuroscience Institute, 808 route de Lennik, Bldg GE, B-1070, Brussels, Belgium.
• ⁴ Sorbonne Université, Institut du Cerveau (ICM) - Paris Brain Institute, AP-HP, INSERM, CNRS, University Hospital Pitié-Salpêtrière, Paris, France.
• ⁵ , Boulogne Billancourt, France.
• ⁶ Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, Orsay, France.
• ⁷ Unit of Neurology of memory and language, Groupe Hospitalier Universitaire Paris - Psychiatrie et Neurosciences, Hôpital Sainte Anne, Université de Paris, Paris, France and Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, 91401, Orsay, France.
• ⁸ Laboratory of Histology, Neuroanatomy and Neuropathology, Faculty of Medicine, Université Libre de Bruxelles, ULB Neuroscience Institute, 808 route de Lennik, Bldg GE, B-1070, Brussels, Belgium. [email protected].