mRNA for kininogens and thiostatins (major acute phase alpha 1-proteins) in the liver of kininogen-deficient rats

W P Fung; J Milland; G Schreiber

doi:10.1016/0049-3848(88)90179-x

mRNA for kininogens and thiostatins (major acute phase alpha 1-proteins) in the liver of kininogen-deficient rats

Thromb Res. 1988 Apr 1;50(1):113-20. doi: 10.1016/0049-3848(88)90179-x.

Authors

W P Fung¹, J Milland, G Schreiber

Affiliation

¹ Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Vic., Australia.

PMID: 3261051
DOI: 10.1016/0049-3848(88)90179-x

Abstract

mRNAs for low and high molecular weight kininogens (1.6 and 3.0 kb in size, respectively) and for two thiostatins (1.6 kb in size) were found in the liver of kininogen-deficient Brown-Norway (BN/Mai Pfd) rats. The levels of mRNAs for thiostatins, but not those for low and high molecular weight kininogens (arising from a single kininogen gene), increased strongly during acute inflammation. The pattern of DNA restriction sites for the kininogen gene and the thiostatin genes in the mutant rat strain was identical to that in at least four other rat strains.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cysteine Endopeptidases / genetics*
Cysteine Proteinase Inhibitors
Immunochemistry
Kininogens / deficiency
Kininogens / genetics*
Liver / metabolism*
Molecular Weight
Protease Inhibitors / genetics*
RNA, Messenger / genetics*
Rats

Substances

Cysteine Proteinase Inhibitors
Kininogens
Protease Inhibitors
RNA, Messenger
Cysteine Endopeptidases