From Skin to Brain: A Parkinson's Disease Patient Transplanted with His Own Cells

Malin Parmar; Anders Björklund

doi:10.1016/j.stem.2020.06.008

From Skin to Brain: A Parkinson's Disease Patient Transplanted with His Own Cells

Cell Stem Cell. 2020 Jul 2;27(1):8-10. doi: 10.1016/j.stem.2020.06.008.

Authors

Malin Parmar¹, Anders Björklund²

Affiliations

¹ Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, 22184 Lund, Sweden. Electronic address: [email protected].
² Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, 22184 Lund, Sweden. Electronic address: [email protected].

PMID: 32619520
DOI: 10.1016/j.stem.2020.06.008

Abstract

In a pioneering study in New England Journal of Medicine, Schweitzer et al. (2020) report on a patient with Parkinson's disease who received a graft of dopamine neurons obtained from in vitro differentiated induced pluripotent stem cells, derived from the patient's own skin fibroblasts, showing the feasibility of autologous transplantation for dopamine cell replacement.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Brain
Cell Differentiation
Dopamine
Dopaminergic Neurons
Humans
Induced Pluripotent Stem Cells*
Parkinson Disease* / therapy
Stem Cell Transplantation

Substances

Dopamine