Synthesis and beta-lactamase inhibitory activity of 9-(2-amidoethenylthio)-9-deoxy derivatives of clavulanic acid

J Antibiot (Tokyo). 1988 Jul;41(7):892-8. doi: 10.7164/antibiotics.41.892.

Abstract

The reaction of activated derivatives of clavulanic acid with substituted amidoethenyl thiolates to give 9-(2-amidoethenylthio)-9-deoxy derivatives is described; the antibacterial/synergistic and beta-lactamase inhibitory activities of the thioethers and their corresponding sulfoxides and sulfones are compared.

MeSH terms

  • Clavulanic Acid
  • Clavulanic Acids / analogs & derivatives*
  • Clavulanic Acids / pharmacology
  • beta-Lactamase Inhibitors*

Substances

  • Clavulanic Acids
  • beta-Lactamase Inhibitors
  • Clavulanic Acid