From bench to bedside: Biosensing strategies to evaluate endocrine disrupting compounds based on epigenetic events and their potential use in medicine

D Araiza-Olivera; M Gutierrez-Aguilar; A M Espinosa-García; J A García-García; N Tapia-Orozco; C Sánchez-Pérez; C Palacios-Reyes; D Escárcega; Demelza N Villalón-López; R García-Arrazola

doi:10.1016/j.etap.2020.103450

From bench to bedside: Biosensing strategies to evaluate endocrine disrupting compounds based on epigenetic events and their potential use in medicine

Environ Toxicol Pharmacol. 2020 Nov:80:103450. doi: 10.1016/j.etap.2020.103450. Epub 2020 Jul 2.

Affiliations

¹ Department of Chemistry and Biomolecules, Institute of Chemistry, UNAM, Mexico. Electronic address: [email protected].
² Department of Biochemistry, Faculty of Chemistry, UNAM, Mexico. Electronic address: [email protected].
³ Unidad de Medicina Genómica, Hospital General de México, Dr. Balmis 148, Mexico City, Mexico. Electronic address: [email protected].
⁴ Department of Education, Hospital General de México, Dr. Balmis 148, Mexico City, Mexico. Electronic address: [email protected].
⁵ Departmentof Food Science and Biotechnology, Faculty of Chemistry, Universidad Nacional Autónoma de México, Ave. Universidad 3000, 04510, Coyoacán, Mexico City, Mexico. Electronic address: [email protected].
⁶ Institute of Applied Sciences and Technology, Faculty of Chemistry, Universidad Nacional Autónoma de México, Ave. Universidad 3000, 04510, Coyoacán, Mexico City, Mexico. Electronic address: [email protected].
⁷ Laboratory of Genetics and Molecular Diagnostics, Juarez Hospital of Mexico, Mexico City, Mexico. Electronic address: [email protected].
⁸ Instituto Tecnológico y de Estudios Superiores de Monterrey, Campus Ciudad de México, calle del Puente 222, Ejidos de Huipulco, Tlalpan 14380, Mexico City, Mexico. Electronic address: [email protected].
⁹ Instituto Politénico Nacional-Escuela Nacional de Ciencias Biológicas, Departamento de Química Orgánica, Prolongación de Carpio y Plande Ayala, colonia Casco de Santo Tomás. Del, Miguel Hidalgo, 11350, Mexico. Electronic address: [email protected].
¹⁰ Departmentof Food Science and Biotechnology, Faculty of Chemistry, Universidad Nacional Autónoma de México, Ave. Universidad 3000, 04510, Coyoacán, Mexico City, Mexico. Electronic address: [email protected].

PMID: 32622887
DOI: 10.1016/j.etap.2020.103450

Abstract

The relationship between endocrine system disorders and health risks due to chemical environmental compounds has become a growing concern in recent years. Involuntary exposure to endocrine disruptors (EDCs) is associated with the worldwide increase of diseases such as cancer, obesity, diabetes, and neurocortical disorders. EDCs are compounds that target the nuclear hormonereceptors (NHR) leading to epigenetic changes. Consequently, the use of biosensing strategies based on epigenetic events have a great potential to provide outstanding information about the exposition of EDCs and their evaluation in human health. This review addresses the novel trends in biosensing EDCs evaluation based on DNA methylation assays associated with different human diseases.

Keywords: Biosensing; DNA methylation; EDC assessment.

Publication types

Review

MeSH terms

Biosensing Techniques / methods*
DNA Methylation / drug effects
DNA Methylation / genetics
Disease / genetics*
Endocrine Disruptors / metabolism
Endocrine Disruptors / toxicity*
Environmental Pollutants / metabolism
Environmental Pollutants / toxicity*
Epigenesis, Genetic / drug effects*
Fluorescence Resonance Energy Transfer
Humans
Receptors, Cytoplasmic and Nuclear / genetics*
Surface Plasmon Resonance

Substances

Endocrine Disruptors
Environmental Pollutants
Receptors, Cytoplasmic and Nuclear