Induction of diverse T cell memory through antibody-mediated activation in mice

Eur J Immunol. 2020 Nov;50(11):1838-1840. doi: 10.1002/eji.202048570. Epub 2020 Jul 29.

Abstract

Recent studies have demonstrated that laboratory mice lack a robust repertoire of memory T cell. Administration of an anti-CD3ε activating antibody (clone 145-2C11) induces persistent CD4 and CD8 T cell memory in both lymphatic and solid organs while maintaining T cell responses and without increased anergy or altering innate immunity.

Keywords: CD 8 T cells; CD4 T cells; T cell activation; T cell memory formation; anti-CD3ε antibody.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology*
  • CD3 Complex / immunology
  • CD4-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / immunology*
  • Clonal Anergy / immunology
  • Immunologic Memory / immunology*
  • Lymphocyte Activation / immunology*
  • Mice
  • Mice, Inbred C57BL

Substances

  • Antibodies, Monoclonal
  • CD3 Complex