Medroxyprogesterone

Medroxyprogesterone is used to prevent pregnancy in females of reproductive potential and for women experiencing amenorrhea due to hormonal imbalance, excluding organic pathologies such as fibroids and uterine cancer. Additionally, medroxyprogesterone is used for abnormal uterine bleeding due to ovulatory dysfunction, prevention of endometrial hyperplasia, pain related to endometriosis, and in patients with inoperable, recurrent, and/or metastatic endometrial carcinoma as adjunctive and/or palliative treatment. Medroxyprogesterone, a progestin, is similar in structure to naturally occurring progesterone. The mechanism of action of progestin involves binding the progesterone receptor in the hypothalamus, female reproductive tract, and pituitary and inhibiting the secretion of gonadotropin-releasing hormone (GnRH).