Abstract
The Prussian blue (PB) based nanostructure is a mixed-valence coordination network with excellent biosafety, remarkable photothermal effect and multiple enzyme-mimicking behaviours. Compared with other nanomaterials, PB-based nanoparticles (NPs) exhibit several unparalleled advantages in biomedical applications. This review begins with the chemical composition and physicochemical properties of PB-based NPs. The tuning strategies of PB-based NPs and their biomedical properties are systemically demonstrated. Afterwards, the biomedical applications of PB-based NPs are comprehensively recounted, mainly focusing on treatment of tumors, bacterial infection and inflammatory diseases. Finally, the challenges and future prospects of PB-based NPs and their application in disease treatment are discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Anti-Inflammatory Agents / chemistry*
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Anti-Inflammatory Agents / pharmacology
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Biocompatible Materials / chemistry*
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Biocompatible Materials / pharmacology
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Ferrocyanides / chemistry*
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Ferrocyanides / pharmacology
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Humans
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Magnetic Resonance Imaging
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Metal Nanoparticles / chemistry*
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Multimodal Imaging
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Nanocomposites / chemistry
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Optical Imaging
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Phototherapy
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Polylysine / chemistry
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Polyvinyls / chemistry
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Porosity
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Pyrrolidines / chemistry
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Theranostic Nanomedicine
Substances
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Anti-Bacterial Agents
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Anti-Inflammatory Agents
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Antineoplastic Agents
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Biocompatible Materials
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Ferrocyanides
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Polyvinyls
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Pyrrolidines
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poly(N-vinylpyrrolidine)
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Polylysine
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ferric ferrocyanide