NEDD8-conjugating enzyme UBC12 as a novel therapeutic target in esophageal squamous cell carcinoma

Shiwen Wang; Jingrong Xian; Lihui Li; Yanyu Jiang; Yue Liu; Lili Cai; Robert M Hoffman; Lijun Jia; Hu Zhao; Yanmei Zhang

doi:10.1038/s41392-020-00226-3

NEDD8-conjugating enzyme UBC12 as a novel therapeutic target in esophageal squamous cell carcinoma

Signal Transduct Target Ther. 2020 Jul 10;5(1):123. doi: 10.1038/s41392-020-00226-3.

Authors

Shiwen Wang^#^{1

2

3

4}, Jingrong Xian^#^{1

2

3

4}, Lihui Li², Yanyu Jiang², Yue Liu^{1

2

3

4}, Lili Cai², Robert M Hoffman⁵, Lijun Jia⁶, Hu Zhao^{7

8

9}, Yanmei Zhang^{10

11

12}

Affiliations

¹ Department of Laboratory Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, China.
² Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
³ Research Center on Aging and Medicine, Fudan University, Shanghai, 200040, China.
⁴ Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, 200040, China.
⁵ Department of Surgery, University of California, San Diego, CA, USA.
⁶ Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. [email protected].
⁷ Department of Laboratory Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, China. [email protected].
⁸ Research Center on Aging and Medicine, Fudan University, Shanghai, 200040, China. [email protected].
⁹ Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, 200040, China. [email protected].
¹⁰ Department of Laboratory Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, China. [email protected].
¹¹ Research Center on Aging and Medicine, Fudan University, Shanghai, 200040, China. [email protected].
¹² Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, 200040, China. [email protected].

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Drug Delivery Systems
Esophageal Neoplasms / drug therapy
Esophageal Neoplasms / enzymology*
Esophageal Squamous Cell Carcinoma / drug therapy
Esophageal Squamous Cell Carcinoma / enzymology*
Humans
NEDD8 Protein / metabolism
Neoplasm Proteins / metabolism*
Ubiquitin-Conjugating Enzymes / metabolism*

Substances

NEDD8 Protein
NEDD8 protein, human
Neoplasm Proteins
Ubiquitin-Conjugating Enzymes
UBE2M protein, human