Intrauterine Transmission of SARS-COV-2 Infection in a Preterm Infant

Julide Sisman; Mambarambath A Jaleel; Wilmer Moreno; Veena Rajaram; Rebecca R J Collins; Rashmin C Savani; Dinesh Rakheja; Amanda S Evans

doi:10.1097/INF.0000000000002815

Intrauterine Transmission of SARS-COV-2 Infection in a Preterm Infant

Pediatr Infect Dis J. 2020 Sep;39(9):e265-e267. doi: 10.1097/INF.0000000000002815.

Authors

Julide Sisman¹, Mambarambath A Jaleel¹, Wilmer Moreno², Veena Rajaram³, Rebecca R J Collins³, Rashmin C Savani¹, Dinesh Rakheja³, Amanda S Evans⁴

Affiliations

¹ From the Division of Neonatal-Perinatal Medicine, Department of Pediatrics.
² Department of Obstetrics and Gynecology.
³ Department of Pathology.
⁴ Division of Infectious Diseases, Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX.

PMID: 32658097
DOI: 10.1097/INF.0000000000002815

Abstract

We present a preterm infant who developed a fever and mild respiratory disease on the second day of life. Infant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nasopharyngeal testing was positive at 24 and 48 hours of life. Placenta histopathology revealed SARS-CoV-2 infection by electron microscopy and immunohistochemistry. Further understanding of the risk factors that lead to in utero transmission of SARS-CoV-2 infection is needed.

Publication types

Case Reports

MeSH terms

Adult
Betacoronavirus / isolation & purification
COVID-19
Coronavirus Infections / transmission*
Coronavirus Infections / virology
Female
Fever / virology
Humans
Infant, Newborn
Infant, Premature*
Infectious Disease Transmission, Vertical*
Pandemics
Placenta / pathology
Pneumonia, Viral / transmission*
Pneumonia, Viral / virology
Pregnancy
Pregnancy Complications, Infectious / diagnosis
Pregnancy Complications, Infectious / virology*
Risk Factors
SARS-CoV-2