Correlations between COVID-19 and burden of dementia: An ecological study and review of literature

J Neurol Sci. 2020 Sep 15:416:117013. doi: 10.1016/j.jns.2020.117013. Epub 2020 Jul 4.

Abstract

Introduction: Current evidence on the association between COVID-19 and dementia is sparse. This study aims to investigate the associations between COVID-19 caseload and the burden of dementia.

Methods: We gathered data regarding burden of dementia (disability-adjusted life years [DALYs] per 100,000), life expectancy, and healthy life expectancy (HALE) from the Global Burden of Disease (GBD) 2017 study. We obtained COVID-19 data from Our World in Data database. We analyzed the association of COVID-19 cases and deaths with the burden of dementia using Spearman's rank correlation coefficient.

Results: Globally, we found significant positive (p < .001) correlations between life expectancy (r = 0.60), HALE (r = 0.58), and dementia DALYs (r = 0.46) with COVID-19 caseloads. Likewise, we found similar correlations between life expectancy (r = 0.60), HALE (r = 0.58) and dementia DALYs (r = 0.54) with COVID-19 mortality.

Conclusion: Health policymakers should clarify a targeted model of disease surveillance in order to reduce the dual burden of dementia and COVID-19.

Keywords: COVID-19; Dementia; Global burden of disease; Mortality.

Publication types

  • Review

MeSH terms

  • Age Distribution
  • COVID-19 / epidemiology*
  • Cause of Death
  • Comorbidity
  • Databases, Factual
  • Dementia / epidemiology*
  • Global Burden of Disease
  • Humans
  • Pandemics