Keratinocyte-Polyamines and Dendritic Cells: A Bad Duet for Psoriasis

Mohna Bandyopadhyay; Adriana T Larregina

doi:10.1016/j.immuni.2020.06.015

Keratinocyte-Polyamines and Dendritic Cells: A Bad Duet for Psoriasis

Immunity. 2020 Jul 14;53(1):16-18. doi: 10.1016/j.immuni.2020.06.015.

Authors

Mohna Bandyopadhyay¹, Adriana T Larregina²

Affiliations

¹ Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
² Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; McGowan Center for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address: [email protected].

PMID: 32668224
DOI: 10.1016/j.immuni.2020.06.015

Abstract

The role of keratinocyte metabolism in psoriasis is not fully elucidated. In this issue of Immunity, Lou et al. describe that interleukin-17 (IL-17) re-programs the urea cycle in keratinocytes increasing polyamines that stabilize RNA-Ag-complexes that upon cellular turnover activate dendritic cells, which amplify psoriasis inflammation.

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MeSH terms

Dendritic Cells
Humans
Keratinocytes
Polyamines
Psoriasis*
RNA*

Substances

Polyamines
RNA