Biologic and Synthetic Cellular and/or Tissue-Based Products and Smart Wound Dressings/Coverings

Surg Clin North Am. 2020 Aug;100(4):741-756. doi: 10.1016/j.suc.2020.05.006. Epub 2020 Jun 17.

Abstract

Cellular and/or tissue-based products (CTPs) have advanced greatly in the past several decades and improve the ability to heal wounds more efficiently. Products can be characterized as nonviable cells, tissue based, animal; nonviable cells, tissue based, human; viable human cells, cultured in vitro, animal substrate; viable human cells, cultured in vitro, synthetic substrate; viable human cells, noncultured, intact tissue. There are approximately 77 different CTPs at the time of this writing, with many more being investigated. Cellular and/or tissue-based product selection, application, postapplication course, and patient selection depend on patient attributes, CTP specifications, and surgeon preference.

Keywords: Bioengineered; Burn; CTP; Graft; Wound treatment.

Publication types

  • Review

MeSH terms

  • Bandages*
  • Bioengineering
  • Biological Dressings
  • Burns / physiopathology
  • Burns / therapy
  • Humans
  • Skin, Artificial
  • Wound Healing / physiology*
  • Wound Infection / physiopathology
  • Wound Infection / prevention & control
  • Wounds and Injuries / physiopathology
  • Wounds and Injuries / therapy*