Four new sucrose diesters of substituted truxinic acids from Trigonostemon honbaensis with their anoctamin-1 inhibitory activity

Bioorg Chem. 2020 Sep:102:104058. doi: 10.1016/j.bioorg.2020.104058. Epub 2020 Jun 30.

Abstract

Truxinic acid sucrose diesters analogs possess interesting chemical structure by the presence of cyclobutane-ring and macrocyclic sucrose diesters moieties which are rarely found from natural sources. This paper describes the isolation and structural elucidation of four new sucrose diesters of substituted truxinic acids, trigohonbanosides A-D (1-4), from the leaves of Trigonostemon honbaensis. Their chemical structures were elucidated by HR-ESI-MS, NMR, and CD spectroscopic methods. At a concentration of 30 µM, compounds 1-4 moderately inhibited ANO-1 activity with inhibitory percentages of 27.7 ± 1.10%, 35.6 ± 0.92%, 43.7 ± 1.61%, and 40.8 ± 1.25%, respectively.

Keywords: Anoctamin-1 inhibitor; Trigohonbanoside; Trigonostemon honbaensis; Truxinic acid sucrose diesters.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anoctamin-1 / antagonists & inhibitors*
  • Humans
  • Molecular Structure
  • Neoplasm Proteins / antagonists & inhibitors*
  • Phenanthrenes / chemistry*
  • Plant Leaves / chemistry*
  • Structure-Activity Relationship

Substances

  • ANO1 protein, human
  • Anoctamin-1
  • Neoplasm Proteins
  • Phenanthrenes
  • trigonostemon E