Current state of kidney transplantation in patients with HIV, hepatitis C, and hepatitis B infection

Clin Transplant. 2020 Oct;34(10):e14048. doi: 10.1111/ctr.14048. Epub 2020 Aug 29.

Abstract

Human immunodeficiency virus (HIV), hepatitis C (HCV), and hepatitis B (HBV) are common chronic viral infections in the end-stage kidney disease (ESKD) patient population that were once considered relative contraindications to kidney transplantation. In this review, we will summarize the current state of kidney transplantation in patients with HIV, HCV, and HBV, which is rapidly evolving. HIV+ patients enjoy excellent outcomes in the modern transplant era and may have new transplant opportunities with the use of HIV+ donors. Direct-acting antivirals for HCV have substantially changed the landscape of care for patients with HCV infection. HBV+ patients now have excellent patient and allograft survival with HBV therapy. Currently, kidney transplantation is a safe and appropriate treatment for the majority of ESKD patients with HIV, HCV, and HBV.

Keywords: HIV; hepatitis B; hepatitis C; kidney transplantation.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / therapeutic use
  • HIV Infections* / complications
  • HIV Infections* / drug therapy
  • Hepatitis B*
  • Hepatitis C* / drug therapy
  • Hepatitis C, Chronic* / drug therapy
  • Humans
  • Kidney Transplantation*

Substances

  • Antiviral Agents