Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference

Marlies Ostermann; Rinaldo Bellomo; Emmanuel A Burdmann; Kent Doi; Zoltan H Endre; Stuart L Goldstein; Sandra L Kane-Gill; Kathleen D Liu; John R Prowle; Andrew D Shaw; Nattachai Srisawat; Michael Cheung; Michel Jadoul; Wolfgang C Winkelmayer; John A Kellum; Conference Participants

doi:10.1016/j.kint.2020.04.020

Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference

Kidney Int. 2020 Aug;98(2):294-309. doi: 10.1016/j.kint.2020.04.020. Epub 2020 Apr 26.

Authors

Collaborators

Conference Participants:
Sean M Bagshaw, Erin F Barreto, Azra Bihorac, Ilona Bobek, Josée Bouchard, Jorge Cerdá, Rajasekara Chakravarthi, Silvia De Rosa, Daniel T Engelman, Lui G Forni, Ulla K Hemmilä, Charles A Herzog, Eric A Hoste, Sarah C Huen, Kunitoshi Iseki, Michael Joannidis, Kianoush B Kashani, Jay L Koyner, Andreas Kribben, Norbert Lameire, Andrew S Levey, Etienne Macedo, Jolanta Małyszko, Melanie Meersch, Ravindra L Mehta, Irene Mewburn, Olga Mironova, Patrick T Murray, Mitra K Nadim, Jenny S Pan, Neesh Pannu, Zhiyong Peng, Barbara Philips, Daniela Ponce, Patricio E Ray, Zaccaria Ricci, Thomas Rimmelé, Claudio Ronco, Edward D Siew, Paul E Stevens, Ashita J Tolwani, Marcello Tonelli, Suvi T Vaara, Marjel van Dam, Anitha Vijayan, Michael Wise, Vin-Cent Wu, Alexander Zarbock

Affiliations

¹ Department of Critical Care, King's College London, Guy's & St. Thomas' Hospital, King's College London, London, UK. Electronic address: [email protected].
² Centre for Integrated Critical Care, The University of Melbourne, Melbourne, Victoria, Australia.
³ Laboratório de Investigação Médica 12, Division of Nephrology, University of Sao Paulo Medical School, Sao Paulo, Sao Paulo, Brazil.
⁴ Department of Emergency and Critical Care Medicine, The University of Tokyo, Tokyo, Japan.
⁵ Prince of Wales Hospital and Clinical School, University of New South Wales, Randwick, NSW, Australia.
⁶ Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA; Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, Ohio, USA.
⁷ Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania, USA.
⁸ Department of Medicine, Division of Nephrology, University of California, San Francisco, San Francisco, California, USA; Department of Anesthesia, Division of Critical Care Medicine, University of California, San Francisco, San Francisco, California, USA.
⁹ William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
¹⁰ Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Alberta, Canada.
¹¹ Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Critical Care Nephrology Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Tropical Medicine Cluster, Chulalongkorn University, Bangkok, Thailand; Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Academy of Science, Royal Society of Thailand, Bangkok, Thailand.
¹² Kidney Disease: Improving Global Outcomes (KDIGO), Brussels, Belgium.
¹³ Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Brussels, Belgium.
¹⁴ Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
¹⁵ Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address: [email protected].

Abstract

In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) published a guideline on the classification and management of acute kidney injury (AKI). The guideline was derived from evidence available through February 2011. Since then, new evidence has emerged that has important implications for clinical practice in diagnosing and managing AKI. In April of 2019, KDIGO held a controversies conference entitled Acute Kidney Injury with the following goals: determine best practices and areas of uncertainty in treating AKI; review key relevant literature published since the 2012 KDIGO AKI guideline; address ongoing controversial issues; identify new topics or issues to be revisited for the next iteration of the KDIGO AKI guideline; and outline research needed to improve AKI management. Here, we present the findings of this conference and describe key areas that future guidelines may address.

Keywords: acute kidney disease; acute kidney injury; fluid management; nephrotoxicity; renal replacement therapy; risk stratification.

Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference

Authors

Collaborators

Affiliations

Abstract

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