Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis

Colton J Garelli; Maggi Ahmed Refat; Padma P Nanaware; Zaida G Ramirez-Ortiz; Mehdi Rashighi; Jillian M Richmond

doi:10.3389/fimmu.2020.01353

Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis

Front Immunol. 2020 Jul 2:11:1353. doi: 10.3389/fimmu.2020.01353. eCollection 2020.

Authors

Colton J Garelli¹, Maggi Ahmed Refat¹, Padma P Nanaware², Zaida G Ramirez-Ortiz³, Mehdi Rashighi¹, Jillian M Richmond¹

Affiliations

¹ Department of Dermatology, University of Massachusetts Medical School, Worcester, MA, United States.
² Department of Pathology, University of Massachusetts Medical School, Worcester, MA, United States.
³ Department of Medicine, University of Massachusetts Medical School, Worcester, MA, United States.

Abstract

Cutaneous Lupus Erythematosus (CLE) is a clinically diverse group of autoimmune skin diseases with shared histological features of interface dermatitis and autoantibodies deposited at the dermal-epidermal junction. Various genetic and environmental triggers of CLE promote infiltration of T cells, B cells, neutrophils, antigen presenting cells, and NK cells into lesional skin. In this mini-review, we will discuss the clinical features of CLE, insights into CLE immunopathogenesis, and novel treatment approaches.

Keywords: CLE; UV light; autoantibodies; autoimmune; cutaneous; interface dermatitis; lupus; lupus band.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Humans
Lupus Erythematosus, Cutaneous / drug therapy*
Lupus Erythematosus, Cutaneous / immunology*
Lupus Erythematosus, Cutaneous / pathology*