High salt diet decreases longevity in the spontaneously hypertensive rat

Clin Exp Pharmacol Physiol. 1988 Apr;15(4):357-9. doi: 10.1111/j.1440-1681.1988.tb01087.x.

Abstract

1. Blood pressure, body weight and mortality rate were examined in female spontaneously hypertensive rats (SHR) of the Okamoto strain maintained on a lifelong high (5% NaCl w/w) or low (0.1% NaCl w/w) salt diet. 2. A high salt diet increased mortality and decreased body weight in SHR, but failed to significantly alter blood pressure up to 24 months of age. 3. Hence, a low salt diet does not appear to be a long-term risk factor and may protect the SHR from cardiovascular accidents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Body Weight / drug effects
  • Female
  • Hypertension / physiopathology*
  • Longevity
  • Male
  • Rats
  • Rats, Inbred SHR
  • Risk Factors
  • Sodium, Dietary / pharmacology*

Substances

  • Sodium, Dietary