A structurally precise AgxAu25- x nanocluster based cancer theranostic platform with tri-targeting/ in situ O2-generation/aggregation enhanced fluorescence imaging/photothermal-photodynamic therapies

Chem Commun (Camb). 2020 Aug 25;56(68):9842-9845. doi: 10.1039/d0cc02946g.

Abstract

The photothermal and photodynamic performances of structurally precise oil-soluble AgxAu25-x (x ≤ 13) nanoclusters were first explored and they were solubilized into new assemblies to form a versatile cancer theranostic platform with tri-targeting/in situ O2-generation/aggregation enhanced fluorescence imaging/photothermal-photodynamic therapy effects, which will provide an important reference for precision theranostics at the atomic level in future.

MeSH terms

  • Amines / chemistry
  • Animals
  • Cell Line, Tumor
  • Ferric Compounds / chemistry
  • Folic Acid / chemistry
  • Gold / chemistry*
  • Humans
  • Light
  • Mice
  • Nanoparticles / chemistry*
  • Nanoparticles / therapeutic use
  • Neoplasms / drug therapy
  • Neoplasms / pathology
  • Neoplasms / therapy
  • Oils / chemistry
  • Optical Imaging
  • Photochemotherapy
  • Phototherapy
  • Silver / chemistry*
  • Singlet Oxygen / metabolism*
  • Theranostic Nanomedicine*
  • Transplantation, Heterologous

Substances

  • Amines
  • Ferric Compounds
  • Oils
  • Singlet Oxygen
  • ferric oxide
  • Silver
  • Gold
  • Folic Acid
  • stearylamine