Early precursor T-cell acute lymphoblastic leukemia: current paradigms and evolving concepts

Omar Castaneda Puglianini; Nikolaos Papadantonakis

doi:10.1177/2040620720929475

Early precursor T-cell acute lymphoblastic leukemia: current paradigms and evolving concepts

Ther Adv Hematol. 2020 Jul 16:11:2040620720929475. doi: 10.1177/2040620720929475. eCollection 2020.

Authors

Omar Castaneda Puglianini¹, Nikolaos Papadantonakis²

Affiliations

¹ Virginia Commonwealth University, Massey Cancer Center, Cellular Immunotherapies and Transplant Program, Richmond, Virginia, USA.
² Department of Hematology and Medical Oncology, Emory University, 1365 Clifton Road, Building B, B4119, Atlanta, Georgia, USA.

Abstract

Early precursor T cell-acute lymphoblastic leukemia (ETP-ALL) is a rare entity characterized by chemo-resistance and a paucity of data regarding optimal management. We review here the literature regarding the management of ETP-ALL and focus on the recent, emerging data, regarding the potential role of molecularly targeted approaches with a focus on venetoclax.

Keywords: ETP-ALL; early precursor T cell acute lymphoblastic leukemia.

Publication types

Review