Ambient air pollution exposure associated with glucose homeostasis during pregnancy and gestational diabetes mellitus

Background: To investigate the effects of air pollution exposure during pregnancy on the indicators of glucose homeostasis and gestational diabetes mellitus (GDM).

Methods: We conducted a birth cohort study in Foshan, China during 2015-2019. Oral glucose tolerance test (OGTT) was administered to each participant during pregnancy. GDM was defined according to the International Association of Diabetes and Pregnancy Study Groups criteria (IADPSG). Air pollutant (fine particulate matter (PM_2.5), particulate matter with an aerodynamic diameter of 10 μm or less (PM₁₀), sulfate dioxide (SO₂), nitrogen dioxide (NO₂) and ozone (O₃)) concentrations from the air monitoring stations in Foshan were used to estimate individual air pollutant exposure during the first two trimesters. Linear and logistic regression models were employed to estimate the associations between air pollution exposure during the first two trimesters and OGTT glucose levels and GDM.

Results: Of 12,842 pregnant women, 3055 (23.8%) had GDM. A 10 μg/m³ increase in PM_2.5, PM₁₀ and SO₂ during trimester 1, trimester 2 and two trimesters were associated with 0.07 mmol/L to 0.29 mmol/L increment in OGTT-fasting glucose levels in single-pollutant model. A 10 μg/m³ increase in NO₂ and O₃ during two trimesters were associated with 0.15 mmol/L and 0.12 mmol/L decrease in OGTT-fasting glucose in single-pollutant model. However, no significant or weaker effects of O₃ during two trimesters on OGTT-fasting glucose were observed in two-pollutant models. Moreover, exposure to PM_2.5, PM₁₀ and SO₂ were associated with increased risk of GDM in both single- and two-pollutant models.

Conclusions: Our study suggests PM_2.5, PM₁₀ and SO₂ exposure during the first two trimesters might increase the risk of GDM.