Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis

Hanbo Li; Xiaoyu Wei; Li Zhou; Weiqi Zhang; Chen Wang; Yang Guo; Denghui Li; Jianyang Chen; Tianbin Liu; Yingying Zhang; Shuai Ma; Congyan Wang; Fujian Tan; Jiangshan Xu; Yang Liu; Yue Yuan; Liang Chen; Qiaoran Wang; Jing Qu; Yue Shen; Shanshan Liu; Guangyi Fan; Longqi Liu; Xin Liu; Yong Hou; Guang-Hui Liu; Ying Gu; Xun Xu

doi:10.1007/s13238-020-00763-1

Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis

Protein Cell. 2021 Jan;12(1):57-66. doi: 10.1007/s13238-020-00763-1.

Authors

Hanbo Li^#^{1

2}, Xiaoyu Wei^#^{1

3

4}, Li Zhou^#^{1

2}, Weiqi Zhang^#^{5

6

7}, Chen Wang^{1

2}, Yang Guo², Denghui Li², Jianyang Chen², Tianbin Liu^{1

4

8}, Yingying Zhang², Shuai Ma^{6

7

9}, Congyan Wang², Fujian Tan², Jiangshan Xu^{1

3

4}, Yang Liu^{1

3

4}, Yue Yuan^{1

3

4}, Liang Chen¹⁰, Qiaoran Wang^{5

6}, Jing Qu^{6

7

11}, Yue Shen^{1

4

8}, Shanshan Liu^{1

2}, Guangyi Fan^{1

2}, Longqi Liu^{1

4}, Xin Liu^{1

2}, Yong Hou^{1

4}, Guang-Hui Liu^{12

13

14}, Ying Gu^{15

16

17}, Xun Xu^{18

19

20

21

22}

Affiliations

¹ BGI-Shenzhen, Shenzhen, 518083, China.
² BGI-Qingdao, Qingdao, 266555, China.
³ BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, 518083, China.
⁴ China National Gene Bank, BGI-Shenzhen, Shenzhen, 518120, China.
⁵ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, China National Center for Bioinformation, Chinese Academy of Sciences, Beijing, 100101, China.
⁶ University of Chinese Academy of Sciences, Beijing, 100049, China.
⁷ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
⁸ Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen, 518083, China.
⁹ National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
¹⁰ Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 40072, China.
¹¹ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
¹² University of Chinese Academy of Sciences, Beijing, 100049, China. [email protected].
¹³ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. [email protected].
¹⁴ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. [email protected].
¹⁵ BGI-Shenzhen, Shenzhen, 518083, China. [email protected].
¹⁶ China National Gene Bank, BGI-Shenzhen, Shenzhen, 518120, China. [email protected].
¹⁷ Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen, 518083, China. [email protected].
¹⁸ BGI-Shenzhen, Shenzhen, 518083, China. [email protected].
¹⁹ China National Gene Bank, BGI-Shenzhen, Shenzhen, 518120, China. [email protected].
²⁰ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. [email protected].
²¹ Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen, 518083, China. [email protected].
²² Synthetic Biology Technology Innovation Center of Shandong Province, Qingdao, 266003, China. [email protected].

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Ambystoma mexicanum / genetics*
Ambystoma mexicanum / immunology
Amputation, Surgical
Animals
Biomarkers / metabolism
Blastomeres / cytology
Blastomeres / immunology
Cell Lineage / genetics*
Cell Lineage / immunology
Connective Tissue Cells / cytology
Connective Tissue Cells / immunology
Epithelial Cells / cytology
Epithelial Cells / immunology
Forelimb
Gene Expression
High-Throughput Nucleotide Sequencing
Humans
Immunity
Peroxiredoxins / genetics*
Peroxiredoxins / immunology
Regeneration / genetics*
Regeneration / immunology
Regenerative Medicine / methods
Single-Cell Analysis / methods*

Substances

Biomarkers
Peroxiredoxins