AIE based GSH activatable photosensitizer for imaging-guided photodynamic therapy

Chem Commun (Camb). 2020 Sep 14;56(71):10317-10320. doi: 10.1039/d0cc02045a. Epub 2020 Aug 6.

Abstract

A novel ferrocene decorated vinyl pyridinium-substituted tetraphenylethylene (TPEPY-S-Fc) linked by a disulfide bond was designed as a GSH activatable photosensitizer by aggregation-induced emission for imaging-guided photodynamic therapy of cancer cells.

MeSH terms

  • Cell Line, Tumor
  • Disulfides / chemistry
  • Fluorescent Dyes / chemistry*
  • Fluorescent Dyes / pharmacology*
  • Glutathione / metabolism*
  • Humans
  • Molecular Imaging*
  • Photochemotherapy*
  • Photosensitizing Agents / chemistry*
  • Photosensitizing Agents / pharmacology*
  • Stilbenes / chemistry
  • Stilbenes / pharmacology

Substances

  • Disulfides
  • Fluorescent Dyes
  • Photosensitizing Agents
  • Stilbenes
  • tetraphenylethylene
  • Glutathione